Relationship of vascular endothelial function and content of serum superoxide dismutase and malonyldiadehyde in patients with coronary heart diseaseChinese Full Text
MA Jian-lin,WANG Sheng,LI Xin-ming,SU Zhe-tan,LI Bin,CHEN Guan-liang,WANG Wei,LIN Jin,ZHANG Jing-wen,WU Zhong(Department of Cardiovascular Disease,Hainan Provincial People’s Hospital,Haikou,Hainan 570311,China)
Abstract: AIM To study the relationship of vascular endothelial function and oxidative stress by detecting the serum content of nitric oxide（NO）,malonyldiadehyde（MDA） and superoxide dismutase（SOD） in patients with coronary heart disease（CHD）.METHODS The levels of serum NO,MDA and SOD in 20 patients with unstable angina pectoris（UA）,20 with stable angina pectoris（SA） and 20 normal cases were measured respectively by nitrate reductase,thiobarbituric acid and xanthine oxidase methods.RESULTS Compared with those in control group,the Levels of NO and SOD in CHD patients significantly decreased（P＜0.01） but the levels of MDA significantly elevated（P＜0.05）.Compared with the patients with SA,the changes of NO were much more pronounced in patients with UA than those with SA（P＜0.05）.CONCLUSION The results suggest that the serum levels of NO and vascular endothelial decrease in patients with CHD,especially those with UA,which is related to the increased oxidative stress.
Keywords：
coronary disease; vascular endothelial function; nitric oxide; malonyldiadehyde; superoxide dismutase;
- DOI：
10.13191/j.chj.2006.03.82.majl.025
- Series：
- Subject：
- Classification Code：
R541.4
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