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Chinese Heart Journal. 2005, (04)

Inhibitory effects of diethyl-2,6-diethyl-4-furny-l, 4-dihydropyridine-3, 5- dicarboxylate on proliferation of cultured vascular smooth muscle cells induced by angiotension IIChinese Full Text

ZHANG Dian-xin~(1),LI Lan-sun ~(1),JIA Guo-liang ~(1),REN Yu-sheng~(2),LIU Bing~(1)(1. Department of Cardiology,Xijing Hospital, Fourth Military Medical University, Xi’an,Shaanxi 710032,China; 2. Department of Cardiology,Changzheng Hospital, Second Military Medical University, Shanghai 200003,China)

Abstract: AIM: To investigate effects of diethyl-2,6diethyl-4-furny-l, 4-dihydropyridine-3, 5- dicarboxylate （EFDP） on proliferation of cultured vascular smooth muscle cells（VSMCs） stimulated by angiotension II（Ang II）. METHODS: The rabbit VSMCs were cultured and the inhibitory effect of EFDP on DNA synthesis in vascular smooth muscle cells stimulated by Ang II were assayed at different times with different concentrations of EFDP by using 3H-TdR incorporation in vitro. RESULTS: Ang II could significantly promote DNA synthesis in quiescent rabbit VSMCs, with a maximal response at 36th h. EFDP significantly inhibited DNA synthesis of VSMCs in a dose-dependent manner, with a maximal response at a concentration of 78.40 μmol/L and at 36th h when the inhibitory rate was 21.37%. CONCLUSION: EFDP significantly inhibits DNA synthesis of ribbit VSMCs induced by Ang II in a dose and time dependent manner.
Keywords：

diethyl-2,6-diethyl-4-furny-l, 4-dihydropyridine-3, 5- dicarboxylate; vascular smooth muscle cells; proliferation; angiotension II;

  • DOI：

    10.13191/j.chj.2005.04.39.zhangdx.011

  • Series：

  • Subject：

  • Classification Code：

    R543.5

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