The effect of L-Arg on cardiac function and arrhythmia of patients with AMIChinese Full Text
ZHANG Suo-long1, JIANG Yi-min2, WANG Jun2, WANG Qin2,GAO Yan-zheng2 ( 1. Deparment of Cardiology, Hengdian Group Hospital,dongyang, Zhejiang 322118 ,China)
Abstract: AIM:To demonstrate the effect of L-arginine（L-Arg）,precurson of endothelium-derived relaxing factor on cardiac function and the incidence of ventricular arrhythmia of patients with acute myocardiac infarction（AMI）. METHODS:Sixty five patients with AMI were divided into two groups randomly, 32 patients were treated with both routine medication and short term administration of L-Arg for 7 to 10 days,The cardiac function parameters were measured by echocardiography and various kinds of arrhythmia were monitored and counted every day, While in control group, 33 patients were administrated with routine medication and short term GIK instead of L-Arg, Cardiac function parameters and the incidence of arrhythmia were treated with the same method as above.RESULTS: parameters reflecting ventricular systolic and diastolic function were improved better in L-Arg treated group than those in control group （P＜0.05 and P＜0.01）, The incidence of ventricular arrhythmia in L-Arg group was lower than that in control group（P＜0.05）. CONCLUSION:The results suggest that L-Arg yield some beneficial effects on improving cardiac function and lowering the incidence of ventricular arrhythmia in patients with AMI.
Keywords：
L-arginine; myocardiac infarction,acute; echocardiography; ventricular function; ventricular arrhythmia;
- DOI：
10.13191/j.chj.2005.02.40.zhangsl.015
- Series：
- Subject：
- Classification Code：
R542.22
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