Vasorelaxing effect of U50,488H on pulmonary artery in rats and underlying mechanismChinese Full Text
SUN Xin, ZANG Yi-min, WANG Yue-min, BI Hui, HUAI Yong, MA Heng, PEI Jian-ming (Department of Physiology, Fourth Military Medical University, Xi’an,Shaanxi 710032, China)
Abstract: AIM: To investigate the relaxation effect and underlying mechanism of U50,488H （a selective κ-opioid receptor agonist） on pulmonary artery in the rat. METHODS: Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. RESULTS: U50,488H at 30～140 μmol/L relaxed the pulmonary artery ring in a dose-dependent manner; The relaxation effect of U50,488H on pulmonary artery was partially endothelium-dependent; The relaxation effect of U50,488H was significantly attenuated in the presence of L-NAME and was not changed by glybenclamide, indomethacin, atropine and propranalol. CONCLUSION: U50,488H is an endothelium-dependent vasodilator, it relaxes the pulmonary artery via nitric oxide （NO）-dependent pathway in the rat.
- DOI：
10.13191/j.chj.2004.06.21.sunx.005
- Series：
- Subject：
- Classification Code：
R332.2
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