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Chinese Heart Journal. 2004, (01)

Relationship between apoptosis and cardiac function in myocardially reperfused ratChinese Full Text

LI Jun-xia 1, JIA Guo-liang 2, LI Dian-gui 3,LI Zhen-bin 1,YU Guo-jie 3,CAI Chun-lin 3(1 Department of Cardiovasology, Bethune International Peace Hospital, Shi jia zhuang,Hebei 050082, China; 2 Department of Cardiology, Xijing Hospital,X i’an,Shaanxi 710 032; 3 Department of Internal Medicine, Hebei Medical University, Shijiazhuang ,Hebei 050031)

Abstract: AIM: To study changes in apoptosis and cardiac functio n with diffe rent durations of reperfusion after myocardial ischemia. METHODS: 60 r ats were di vided randomly into 5 groups, sham-operated （observing for 12 h in operated con trol ）, 45 min of ischemia followed by 0 h of reperfusion（I 45 min R 0 h）, I 45 min R 2 h, I 45 min R4h and I 45 min R 8 h. The myocardial cell apoptosis was deter mined wit h t erminal deoxynucleotidyl transferase -mediated dUTP-fluorescein nick end lab el ing （TUNEL） method. RESULTS: Cardiomyocyte apoptosis varied with the d uration of reperfusion. The apoptotic index（AI） in myocytes were highest in rats with I 45 min R 2?4 h（24±4;20±3）;the apoptosis was positively correlated to CK（ r=0.92 , P＜0.05）,but negatively correlated to ventricular function （r=-0.81, P＜0.0 5）. CONCLUSION: The number of apoptotic myocytes varied with the duration of myocardial reperfusion. Changes in apoptosis may be involved in the proces s of myocardial ischemia reperfusion injury.
Keywords：

myocardial reperfusion injury; cardiac function; apoptosis;

  • DOI：

    10.13191/j.chj.2004.01.53.lijx.017

  • Series：

  • Subject：

  • Classification Code：

    R541

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