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Chinese Heart Journal. 2003, (06)

The effect of calcitonin gene-related peptide on vasoconstriction induced by arginine vasopressinChinese Full Text

YE Ji-xian 1,LI Hong-mei 1,HUANG Jing 1,ZHAO Lian-you 2 (1 Department of Cardiology, 323 Hospital of PLA,Xi’an,Shaanxi 710054,China)

Abstract: AIM:To investigate the effect of calcitonin gene-related pe ptide（CGRP） on the vasoconstriction induced by arginine vasopressin（AVP）. METHODS:The aortic vascular smooth muscle cell（VSMC） of rat was cultured to determine the cytosolic free Ca 2+ concentration （[Ca 2+ ] i） in the presence of CGRP and AVP. RESULTS:AVP increased [Ca 2+ ] i,which was signi ficant ly attenuated by CGRP. CONCLUSION:CGRP plays the inhibitory effect on AVP-induced vasoconstriction by confining increased [Ca 2+ ] i of VSMC.
Keywords：

calcition gene-related peptide; arginine vasopressin; vascu lar smooth muscle cells; cytosolic free Ca 2+;

  • DOI：

    10.13191/j.chj.2003.06.15.yejx.004

  • Series：

  • Subject：

  • Classification Code：

    R54

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