Effects of irbesartan on cytokins secretion by rabbit vascular smooth muscle cellsChinese Full Text
WU Xing-li,WANG Shi-wen,SHI Wei-wei,YANG Ding-you,GAO Yu-ling,ZHAO Yu-sheng (Institute of Geriatric cardiology,General Hospital of PLA,Beijing 100853,China)
Abstract: AIM:To investigate the effects of irbesartan（Irb） on cytokins secretion by vascular smooth muscle cells（VSMC）. METHODS:Rabbit aortic VSMCs were cultured in 6 groups: control,the low density lipoprotein,the oxidized low density lipoprotein（oxLDL）,the Irb+oxLDL and the Irb of different concentrations and time groups. The level of tumor necrosis factor alpha（TNFα）,interleukin-6（IL-6） and interleukin-8（IL-8） were evaluated by ELISA method.RESULTS:oxLDL increased the secretion of TNFα,IL-6 and IL-8 by 6.4～8.5-fold in 8 h. Irb decreased the cytockins secretion in a concentration（0.01～100 μmol/L）-and time（1～24 h）-dependent manner,and inhibited the above effects of oxLDL. CONCLUSION:Irb could regulate the biological effects of VSMC by inhibiting base and oxLDL-stimulated cytokins secretion.
- DOI：
10.13191/j.chj.2003.05.12.wuxl.004
- Series：
- Subject：
- Classification Code：
R543.5
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