Effects of adenoviral vector-mediated Fas ligand gene introduction on neointima after rat carotid injuryChinese Full Text
TAO Hong 1, CHEN Li-dong 1, HUANG Cong-xin 2, ZHANG Qun-lin 1, WANG Jia-ning 1, HUANG Yong-zhang 1 (1 Department of Cardiology, Affliated Taihe Hospital, Yunyang Medical College, Shiyan, Hubei 442000,China)
Abstract: AIM: To study the effects of Fas ligand（FasL） gene transfer mediated by adenoviral vector on neointimal hyperplasia after rat carotid injury. METHODS: Restenosis model was established in SD rat and FasL gene was transduced into the carotid artery by adenoviral vector after carotid balloon injury and neointimal/media area ratio in local artery 14 days after gene tranafer was measured. RESULTS: FasL gene was successfully transducted into the carotid artery after balloon injury. Neointimal/media area ratio was reduced 73% （P＜0.01） compared with the control group β gal 14 days after gene transfer. CONCLUSION: FasL gene transfer to the vessel wall inhibits neointimal formation. It is an effective gene therapy to restenosis.
- DOI：
10.13191/j.chj.2003.04.22.taoh.007
- Series：
- Subject：
- Classification Code：
R543.5
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