Prevention of restenosis in rabbits with32P-radiactive stentChinese Full Text
GAO Dong sheng,CHEN Run fen,HUANG Ding jiu (Department of Cardiology,Renji Hospital,Shanghai Second Medical University,Shanghai 200001,China)
Abstract: AIM:To evaluate the preventive effect of 32 P stent on restenosis after PTCA and to investigate the mechanism. METHODS:6 32 P β emitting stents made by chemical electroplation and pared with 6 nonradioactive stents were placed in both sides of 6 rabbits′iliac arteries. The animals were sacrificed 30 days later. The intimal area and the lumen area of arteries were measured by histology image and the level of PDGF in arteries with stents implantation were measured by RT PCR. RESULTS:12 stents were implanted successfully. Compared with the nonradiactine stents,the lumen area in the arteries with 32 P stents implants was greater （3.41±0.19 mm 2 vs 2 97±0.40 mm 2, P ＜0.05）, but the neointimal area was much smaller（0.49±0.21 mm 2 vs 0.58±0.17 mm 2, P ＜0.01）. Compared with the control arteries,the expression of PDGF of arteries with radiactive stents were much lower（ P ＜0.01）. CONCLUSION: 32 P stent could decrease the expression of PDGF in arteries,reduce the stimulation to SMC migration,thus preventing restenosis significantly.
- DOI：
10.13191/j.chj.2003.01.6.gaodsh.002
- Series：
- Subject：
- Classification Code：
R541.4
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