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Chinese Heart Journal. 2002, (06)

Protective effects of trimetazidine on myocardial ischemia-reperfusion injuryChinese Full Text

GAO Si hai,LI Ping,ZHANG Kai lun,YANG Chen yuan (Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan, Hubei 430022,China)

Abstract: AIM:To study the protective effects of trimetazidine on myocardial ischemia reperfusion injury. METHODS:The study consisted of two groups of rats. Group A（ n =12）,received cardioplegia with trimetazidine. Group B（ n =12）,received same cardioplegia only. Isolated rat hearts were subjected to preperfusion for 30 min,ischemia for 120 min and reperfusion for 30 min using a modified Langendorff Neely model with modified Krebs Henseleit buffer at 37℃. The hemodynamic parameters,myocardial enzyme（CPK,LDH）,myocardial superoxide dismutase（SOD）,myocardial ATP level,myocardial lipid peroxide（LPO） and myocardial ultrastructure were measured before ischemia and during reperfusion. RESULTS:Recovery of cardial function and myocardial ultrastructure in Group A was significantly better than Group B. Myocardial enzyme （CPK,LDH） and LPO in group A was significantly lower than in Group B（ P ＜0.01）. SOD was significantly higher than Group B（ P ＜0.01）. Myocardial ATP level was significantly higher than Group B（ P ＜0.01）.CONCLUSION:Trimetazidine supplement in cadioplegia significantly alleviated reperfusion mediated myocardial injury after global ischemia,suggesting good myocardioprotective actions.
Keywords：

trimetazidine; myocardial reperfusion injury; myocardial protection;

  • DOI：

    10.13191/j.chj.2002.06.7.gaosh.003

  • Series：

  • Subject：

  • Classification Code：

    R542.2

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