心肌细胞Ca2+信号与心肌肥厚研究新进展
杨永健,祝善俊,祝之明
第三军医大学新桥医院心内科!重庆400037第三军医大学新桥医院心内科!重庆400037第三军医大学大坪医院高血压内分泌科
Abstract: 心肌细胞内 Ca2 +信号形成涉及胞外 Ca2 +的内流及内贮 Ca2 +的释放。Ca2 +信号以多种形式表现如钙微粒、钙闪烁、钙波、钙振荡、全细胞性瞬时性钙增高等。Ca2 +信号主要是通过钙振荡或钙跃升的频率来编码外来信息 ,钙峰的幅度、持续时间及 Ca2 +信号的空间位置均参与对外来信息的编码。异常的 Ca2 +信号编码与心肌肥厚关系密切 ,肥厚的心肌钙转运异常导致 Ca2 +超载加重 ,使心功能恶化 ,最终导致心律失常。
- DOI:
10.13191/j.chj.2001.03.62.yangyj.023
- Series:
- Subject:
- Classification Code:
R331.31
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