Insulin stimulates translocation of GLIT1 and glucose uptake in canine myocardium in vivoChinese Full Text
YIN Ren fu 1,CHEN Jin ming 1,WU Zong gui 1,QIU Shao hua 1,WANG Yong mei 1,KONG Xian tao 2 (1 Department of Cardiology,Changzeng Hospital,Second Military Medical University,Shanghai 200003,China)
Abstract: AIM:To investigate whether insulin stimulates the translocation of GLUT1 and glucose uptake in canine myocardium. METHODS:Physiological metabolic parameters were determined by autoanalyser and GLUT1 was studied by immunoblot analysis. RESULTS:Insulin increased GLUT1 significantly in sarcolemma of canine myocardium [（42±5）% vs （63±8）%, P ＜0.05],but decreased the GLUT1 content in intracellular membrane. And insulin also increased the myocardiol glucose uptake, as compared with the baseline. CONCLUSION:Insulin stimulation results in GLUT1 translocation and then increases glucose uptake in canine myocardium. Insulin helps to increase the uptake and utilization of myocardial glucose.
Keywords：
- DOI：
10.13191/j.chj.2001.03.16.yinrf.005
- Series：
- Subject：
- Classification Code：
R331.31
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