Study of serum TNF,IL-6 levels in patients with coronary heart disease and their relationshipChinese Full Text

DU Deng gui,HE Hai ming,SHI Gen lin (Department of Cardiology,Jiangsu Provincial Corp Hospital,Chinese People′s Armed Police Force,Yangzhou Jiangsu 225003,China)

Abstract: AIM:To study the changes of serum tumor necrosis factor（TNF） and interleukin 6 （IL 6） in patients with coronary heart disease （CHD） and their clinical significance. METHODS:The serum TNF and IL 6 in 45 patients with CHD and in 30 healthy controls were determined by using radioimmunoassay （RIA）. RESULTS:The serum TNF and IL 6 levels in patients with CHD were markedly higher than those in the controls （ P ＜0.01）,and especially those in patients with myocardial infarction were more obvious （ P ＜0.01）. The serum TNF and IL 6 levels in myocardial infarction were much higher than those in myocardial ischemia （ P ＜0.01）. In patients with myocardial infarction,the serum TNF and IL 6 levels in AMI patients were higher than those in OMI patients （ P ＜0.05）. In myocardial ischemia patients,the serum TNF and IL 6 level at heart function stages Ⅲ^Ⅳ, were higher than those at heart function stages Ⅰ^Ⅱ （ P ＜0.01）. The serum TNF level was obvious positively correlated with IL 6 （ r =0.73, P ＜0.01）. CONCLUSION:The levels of serum TNf and IL 6 are closely related to the severity of CHD. The study has implied that TNF and IL 6 may contribute to the formation and progression of CHD.

Keywords：

coronary disease; tumor necrosis factor; interleukin 6。;

DOI：
10.13191/j.chj.2001.03.11.dudg.003
Series：
Subject：
Classification Code：
R541.4

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Study of serum TNF,IL-6 levels in patients with coronary heart disease and their relationshipChinese Full Text

DU Deng gui,HE Hai ming,SHI Gen lin (Department of Cardiology,Jiangsu Provincial Corp Hospital,Chinese People′s Armed Police Force,Yangzhou Jiangsu 225003,China)

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