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心功能杂志. 1998, (01)

Effects of amlodipine on cardiac function of patients with coronary artery disease complicated by heart failureChinese Full Text

Ma Jianlin1,Mao Huanyuan21Hospital of Hainan Province, Haikou 570311 2Institute of Cardiovascular Diseases, Tongji Medical University

Abstract: For the purpose of investigating effects of amlodipine on cardiac function of patients with coronary artery disease complicated by heart fuilure,cardiac functional indices of left and right ventricles as well as mean artery pressure（MAP） and heart rate（HR） were measured by nuclide cardiovascular radiography in 28 patients with coronary artery disease complicated by heart failure（NYHA classes Ⅱ￣Ⅳ） who had taken 10 mg amlodipine as experimental group and 12 class Ⅰ patients with coronary artery disease who had taken placebo as control group. The results showed that MAP, the left ventricular ejection fraction（LVEF）,the peak ejection rate（PER）, the time of its occurrence（TEO）,and the right ventricular ejection fraction（RVEF） were of siginificant difference,whereas the peak filling rate（PFR） and the time of its occurrence（TFO）,as well as HR were of no significant difference before and after taking the drug. All indices mentioned above were significantly different in class Ⅲ as well as in class Ⅳ patients and were not in class Ⅱ patients. The results suggest that the drug may effectively improve systolic performance in patients with coronary artery disease complicated by heart failure while it can lower MAP without affecting HR. The effect of amlodipine on cardiac function seems to be closely related to severity of heart failure.
Keywords：

coronary artery disease heart failure amlodipine gated bloodpool imaging;

  • DOI：

    10.13191/j.chj.1998.01.19.majl.009

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  • Classification Code：

    R541.4

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