Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

Ryodai YAMAMURA; Koshi NAKAMURA; Naoya KITADA; Tomoyasu AIZAWA; Yu SHIMIZU; Kiminori NAKAMURA; Tokiyoshi AYABE; Takashi KIMURA; Akiko TAMAKOSHI

doi:10.12938/bmfh.19-010

Full Paper

Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

Ryodai YAMAMURA, Koshi NAKAMURA, Naoya KITADA, Tomoyasu AIZAWA, Yu SHIMIZU, Kiminori NAKAMURA, Tokiyoshi AYABE, Takashi KIMURA, Akiko TAMAKOSHI

Author information

Ryodai YAMAMURA
Graduate School of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan
Koshi NAKAMURA
Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan
Naoya KITADA
Graduate School of Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan
Tomoyasu AIZAWA
Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan
Yu SHIMIZU
Graduate School of Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan
Kiminori NAKAMURA
Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan
Tokiyoshi AYABE
Faculty of Advanced Life Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan
Takashi KIMURA
Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan
Akiko TAMAKOSHI
Faculty of Medicine, Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan

Keywords: gut microbiota, fecal short-chain fatty acids, serum short-chain fatty acids, dietary intake, human

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Supplementary material

2020 Volume 39 Issue 1 Pages 11-17

DOI https://doi.org/10.12938/bmfh.19-010

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Abstract

In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22–51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body.

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