The Japanese Journal of Veterinary Science
Online ISSN : 1881-1442
Print ISSN : 0021-5295
ISSN-L : 0021-5295
Biological Effects of Lipopolysaccharide from Achromobacter stenohalis on Lymphocytes and Macrophages
Hiroshi ISOGAI, Emiko ISOGAI, Nobuhiro FUJII, Keiji OGUMA, Koo Lee CHANG, Eizaburo DEGUCHI, Kazuo TAKANO, Masanobu HAYASHI, Shigeo NAMIOKA
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Keywords: Achromobacter stenohalis, biological effect, lipopolysaccharide, lymphocyte, macrophage
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1989 Volume 51 Issue 5 Pages 1003-1010

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Abstract

The immunopotenciating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1, (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.

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