Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
The Feline Herpesvirus Type 1 ICP4 Down-Regulates Feline Immunodeficiency Virus Long Terminal Repeat (LTR)-Directed Gene Expression Via the C/EBP Site in the LTR
Yasushi KAWAGUCHIKen MAEDAMarcelo R. PECORAROYasuo INOSHIMAHyung-Kwan JANGMariko KOHMOTOKiyoko IWATSUKIYasuhiro IKEDAMasahiro SHIMOJIMAYukinobu TOHYAChieko KAITakeshi MIKAMI
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1995 Volume 57 Issue 6 Pages 1129-1131

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Abstract

We investigated effects of feline herpesvirus type 1 (FHV-1) ICP4 on feline immunodeficiency virus (FIV) long terminal repeat (LTR)-directed gene expression by transient transfection assay in Crandell feline kidney cells. We demonstrated that FHV-1 ICP4 significantly stimulates the FIV LTR after introduction of site-specific mutation of the C/EBP site in the LTR, and the C/EBP site is sufficient to confer inhibitory effects by FHV-1 ICP4 on a heterologous promoter. These results indicate that FHV-1 ICP4 possesses both ability to transactivate FIV LTR-directed gene expression and to down-regulate the FIV LTR via the C/EBP site.

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© The Japanese Society of Veterinary Science
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