Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Topographic Relationship between Senile Plaques and Cerebrovascular Amyloidosis in the Brain of Aged Dogs
Akinori SHIMADAMitsuru KUWAMURATsuyoshi AWAKURATakashi UMEMURAKuniyasu TAKADAEisaku OHAMAChitoshi ITAKURA
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JOURNAL FREE ACCESS

1992 Volume 54 Issue 1 Pages 137-144

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Abstract

The distributions of senile plaques (SP) and cerebrovascular amyloidosis (CA) were studied by employing thioflavin S and modified Bielschowsky stains, and β-protein immunohistochemistry on serial sections of the brains of aged dogs older than 10 years. Mature and perivascular plaques, both of which contained compact amyloid deposits, always showed a close topographic relationship to CA. In contrast, the majority of diffuse plaques showed no topographic relationship to CA. Cell bodies of neurons and/or glia were almost always involved in the diffuse plaques. In addition, β-protein immunohistochemistry demonstrated amyloid deposits on the periphery of occasional neurons. These findings suggest that different mechanisms may be involved in the development of the different subtypes of SP in the brains of aged dogs.

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© The Japanese Society of Veterinary Science
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