Susceptibility of common dabbling and diving duck species to clade 2.3.2.1 H5N1 high pathogenicity avian influenza virus: an experimental infection study

Kosuke SODA; Yukiko TOMIOKA; Tatsufumi USUI; Hiroichi OZAKI; Hiroshi ITO; Yasuko NAGAI; Naoki YAMAMOTO; Masatoshi OKAMATSU; Norikazu ISODA; Masahiro KAJIHARA; Yoshihiro SAKODA; Ayato TAKADA; Toshihiro ITO

doi:10.1292/jvms.23-0122

Avian Pathology

Susceptibility of common dabbling and diving duck species to clade 2.3.2.1 H5N1 high pathogenicity avian influenza virus: an experimental infection study

Kosuke SODA, Yukiko TOMIOKA, Tatsufumi USUI, Hiroichi OZAKI, Hiroshi ITO, Yasuko NAGAI, Naoki YAMAMOTO, Masatoshi OKAMATSU, Norikazu ISODA, Masahiro KAJIHARA, Yoshihiro SAKODA, Ayato TAKADA, Toshihiro ITO

Author information

Kosuke SODA
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori, Japan
Yukiko TOMIOKA
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Tatsufumi USUI
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori, Japan
Hiroichi OZAKI
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori, Japan
Hiroshi ITO
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori, Japan
Yasuko NAGAI
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Naoki YAMAMOTO
Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
Present address: Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Masatoshi OKAMATSU
Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
Norikazu ISODA
Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
Masahiro KAJIHARA
Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Hokkaido, Japan
Yoshihiro SAKODA
Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Hokkaido, Japan
Ayato TAKADA
Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Hokkaido, Japan
International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Hokkaido, Japan
Toshihiro ITO
Department of Joint Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Japan
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori, Japan

Keywords: avian viral disease, experimental pathology, influenza virus, pathogenicity, wildlife disease

JOURNAL OPEN ACCESS
Supplementary material

2023 Volume 85 Issue 9 Pages 942-949

DOI https://doi.org/10.1292/jvms.23-0122

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Abstract

In the winter of 2010–2011, Japan experienced a large outbreak of infections caused by clade 2.3.2.1 H5N1 high pathogenicity avian influenza viruses (HPAIVs) in wild birds. Interestingly, many tufted ducks (Aythya fuligula), which are migratory diving ducks, succumbed to the infection, whereas only one infection case was reported in migratory dabbling duck species, the major natural hosts of the influenza A virus, during the outbreak. To assess whether the susceptibility of each duck species to HPAIVs was correlated with the number of cases, tufted duck and dabbling duck species (Eurasian wigeon, Mareca penelope; mallard, Anas platyrhynchos; Northern pintail, Anas acuta) were intranasally inoculated with A/Mandarin duck/Miyazaki/22M807-1/2011 (H5N1), an index clade 2.3.2.1 virus previously used for experimental infection studies in various bird species. All ducks observed for 10 days post-inoculation (dpi) mostly shed the virus via the oral route and survived. The tufted ducks shed a higher titer of the virus than the other dabbling duck species, and one of them showed apparent neurological symptoms after 7 dpi, which were accompanied by eye lesions. No clinical symptoms were observed in the dabbling ducks, although systemic infection and viremia were observed in some of them sacrificed at 3 dpi. These results suggest that the susceptibility of clade 2.3.2.1 HPAIVs might differ by duck species.

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