Effect of acute volume loading on left atrial strain values derived from two-dimensional speckle tracking echocardiography in dogs

Angkhana DERMLIM; Tatsuyuki OSUGA; Kensuke NAKAMURA; Tomoya MORITA; Khoirun NISA; Kazuyoshi SASAOKA; Rommaneeya LEELA-ARPORN; Noriyuki NAGATA; Masahiro TAMURA; Noboru SASAKI; Hiroshi OHTA; Mitsuyoshi TAKIGUCHI

doi:10.1292/jvms.19-0012

Internal Medicine

Effect of acute volume loading on left atrial strain values derived from two-dimensional speckle tracking echocardiography in dogs

Angkhana DERMLIM, Tatsuyuki OSUGA, Kensuke NAKAMURA, Tomoya MORITA, Khoirun NISA, Kazuyoshi SASAOKA, Rommaneeya LEELA-ARPORN, Noriyuki NAGATA, Masahiro TAMURA, Noboru SASAKI, Hiroshi OHTA, Mitsuyoshi TAKIGUCHI

Author information

Angkhana DERMLIM
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Tatsuyuki OSUGA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Kensuke NAKAMURA
Laboratory of Internal Medicine, Organization for Promotion of Tenure Track, University of Miyazaki, Miyazaki 889-2192, Japan
Tomoya MORITA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Khoirun NISA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Kazuyoshi SASAOKA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Rommaneeya LEELA-ARPORN
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Noriyuki NAGATA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Masahiro TAMURA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Noboru SASAKI
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Hiroshi OHTA
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan
Mitsuyoshi TAKIGUCHI
Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 006-0818, Japan

Keywords: canine, deformation analysis, echocardiography, left atrial function, volume overload

JOURNAL FREE ACCESS

2019 Volume 81 Issue 7 Pages 949-957

DOI https://doi.org/10.1292/jvms.19-0012

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Abstract

The purpose of this study was to evaluate the cardiac acute volume loading effect on left atrial (LA) strain and strain rate (SR) parameters derived from two-dimensional speckle tracking echocardiography (2D-STE) in healthy dogs. Six healthy beagles were anesthetized and subjected to increase cardiac preload by intravenous infusion with lactated Ringer solution at 150 ml/kg/hr for 90 min. A Swan-Ganz catheter was placed to directly measure the mean pulmonary capillary wedge pressure (PCWP). Echocardiography was performed before (baseline) and at 15, 30, 45, 60, 75, and 90 min after acute volume loading began. Apical 4-chamber images focused on the LA were digitally recorded for later strain and SR analysis via 2D-STE. Acute volume loading significantly increased from baseline during LA strain and SR as assessed by the speckle tracking–based technique during reservoir and conduit function at 15 to 90 min after volume load began, and strain indices representing booster pump function were enhanced at 45 to 90 min. In addition, acute volume loading resulted in a significantly greater PCWP after fluid infusion. On multiple regression analysis, quadratic regression analysis was a better fit for the relationship between PCWP and all LA functional indices. Our findings indicated that LA function analyzed by strain and SR was enhanced during cardiac acute volume loading in healthy dogs. The change in strain and SR during acute volume loading should be interpreted with caution during the diagnosis of heart diseases related to volume overload.

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