Clinicopathological Characteristics of Esophageal Squamous Papillomas in Japanese Patients—With Comparison of Findings from Western Countries

Kuniko Takeshita; Shin-ichi Murata; Shoji Mitsufuji; Naoki Wakabayashi; Keisho Kataoka; Yasunari Tsuchihashi; Takeshi Okanoue

doi:10.1267/ahc.39.23

REGULAR ARTICLE

Clinicopathological Characteristics of Esophageal Squamous Papillomas in Japanese Patients—With Comparison of Findings from Western Countries

Kuniko Takeshita, Shin-ichi Murata, Shoji Mitsufuji, Naoki Wakabayashi, Keisho Kataoka, Yasunari Tsuchihashi, Takeshi Okanoue

Author information

Kuniko Takeshita
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
Shin-ichi Murata
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Shoji Mitsufuji
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
Naoki Wakabayashi
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
Keisho Kataoka
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
Yasunari Tsuchihashi
Department of Clinical Pathology Research, Louis Pasteur Centre for Medical Research
Takeshi Okanoue
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science

Keywords: squamous papilloma, esophagus, gastroesophageal reflux diseases, reflux esophagitis, human papilloma virus

JOURNAL FREE ACCESS

2006 Volume 39 Issue 1 Pages 23-30

DOI https://doi.org/10.1267/ahc.39.23

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Abstract

To clarify the characteristics of esophageal squamous papillomas (ESPs) in the Japanese population, we investigated 38 ESPs of 35 Japanese patients from a file with 17,387 upper gastrointestinal endoscopies in our university hospital. ESPs accounted for 0.20% of the total number of endoscopies and comprised 21 females and 14 males with an average age of 59.2 years. More than half of the ESPs (52.6%) were located in the middle esophagus. The ratio of human papilloma virus (HPV) positive ESPs was 10.5% and all were located in the middle esophagus of female patients only. HPV-positive ESP cases were younger (46.8 years) than HPV-negative cases (60.8 years). Based on comparison with the reports from western countries, we attribute the low prevalence in the lower esophagus to the relatively fewer occurrences of severe reflux esophagitis (RE) due to chronic gastritis with low gastric acid secretion among Japanese patients.

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