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21 April 2020 : Case report  

First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia

Zhiheng Zhang123BE, Weiqiang Ju123A, Yunhua Tang123E, Linhe Wang123B, Caihui Zhu123B, Ningxin Gao123C, Qiang Zhao123C, Shanzhou Huang123B, Dongping Wang123D, Lu Yang4B, Ming Han123B, Wei Xiong4B, Linwei Wu123D, Maogen Chen123D, Yixi Zhang123D, Yanling Zhu5B, Chengjun Sun123D, Xiaofeng Zhu123A, Zhiyong Guo123E*, Xiaoshun He123AE

DOI: 10.12659/AOT.921529

Ann Transplant 2020; 25:e921529

Abstract

BACKGROUND: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China.

CASE REPORT: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation.

CONCLUSIONS: NMP provides a potential tool for preservation and assessment of ECD livers in China.

Keywords: Donor Selection, Liver Transplantation, Organ Preservation, Bile, cold ischemia, End stage liver disease, Graft Survival, Perfusion, young adult

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358