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SST-2 tumor inoculation is a useful model for studying the anti-tumor immune response in SHR rats

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objective

The purpose of the present study was to investigate the relation between the dose of tumor cell inoculation (especially the doses less than minimum required to evoke tumor growth) and the anti-tumor immune system, particularly lymphoblast formation and cytotoxic activity of lymphcytes.

Method

We inoculated rats with various doses of SST-2 tumor cells and examined natural killer (NK) cell activity and lymphoblast formationin vitro.

Result

The results showed that the cytotoxicities against SST-2 cells and lymphoblast formation of lymphocytes were enhanced by small dose inoculation of tumor cells that could not induce tumor growth.

Conclusion

It was suggested that was lymphocutes play an important role as an anti-tumor immune system at small doses of tumor inoculation, which appears to reflect an early stage of tumor growthin vivo. It was also suggested that SST-2 tumor inoculation might be a useful model for studying the anti-tumor immune response in SHR rats.

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Correspondence to Naomi Nishio.

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Nishio, N., Oishi, K. & Machida, K. SST-2 tumor inoculation is a useful model for studying the anti-tumor immune response in SHR rats. Environ Health Prev Med 8, 1–5 (2003). https://doi.org/10.1007/BF02897936

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  • DOI: https://doi.org/10.1007/BF02897936

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