CJO - Abstract - Cupular deposits and aminoglycoside administration in human temporal bones

The Journal of Laryngology & Otology (2005), 119: 87-91 Cambridge University Press

Copyright © 2005 Royal Society of Medicine Press

doi:10.1258/0022215053420040

Published online by Cambridge University Press 16 Mar 2006

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(RF) Otorhinolaryngology

Cupular deposits and aminoglycoside administration in human temporal bones

Takeshi Kusunoki MD ^a1, Sebahattin Cureoglu MD ^a1, Patricia A Schachern BS ^a2, Mehmet F Oktay MD ^a1, Hisaki Fukushima MD ^a1 and Michael M Paparella MD ^a3
^a1 International Hearing Foundation, Minneapolis, Minnesota, USA
^a2 Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minnesota, USA
^a3 Ear Head and Neck Clinic, Minneapolis, Minnesota, USA

Article author query

kusunoki t [Medline] [Google Scholar]

cureoglu s [Medline] [Google Scholar]

schachern a [Medline] [Google Scholar]

oktay f [Medline] [Google Scholar]

fukushima h [Medline] [Google Scholar]

paparella m [Medline] [Google Scholar]

Abstract

In this study, the deposits of basophilic material on the cupula of the semicircular canals in temporal bones from patients who had aminoglycoside administration within six months prior to death were compared with normal temporal bones. Subjects were divided into two groups. Group I included 24 normal control temporal bones age-matched to group II patients. Group II consisted of 23 temporal bones that had received aminoglycosides within six months prior to death. All temporal bones were examined under light microscopy.

One (4.2 per cent) of 24 temporal bones in group I (normal) showed basophilic deposits. In group II, deposits were observed in 8 (34.8 per cent) of 23 temporal bones. The prevalence of basophilic deposits in group II was significantly higher than group I.

This study demonstrates that within six months after aminoglycoside administration there is an increased prevalence of basophilic deposits on the surface of the cupula. Such changes may be related to the benign paroxysmal positional vertigo (BPPV) seen in some patients who have had aminoglycoside administration.

Key Words: Semicircular Canals; Aminoglycosides; Temporal Bone; Vertigo.