Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium

Hideaki Nouchi; Naoaki Kiryu; Mikio Kimata; Yayoi Tsuneoka; Shogo Hamaguchi; Iyuki Namekata; Akira Takahara; Koki Shigenobu; Hikaru Tanaka

doi:10.1254/jphs.10205SC

Short Communications

Developmental Changes in Action Potential Prolongation by K⁺-Channel Blockers in Chick Myocardium

Hideaki Nouchi, Naoaki Kiryu, Mikio Kimata, Yayoi Tsuneoka, Shogo Hamaguchi, Iyuki Namekata, Akira Takahara, Koki Shigenobu, Hikaru Tanaka

Author information

Hideaki Nouchi
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Naoaki Kiryu
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Mikio Kimata
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Yayoi Tsuneoka
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Shogo Hamaguchi
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Iyuki Namekata
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Akira Takahara
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Koki Shigenobu
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
Hikaru Tanaka
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

Keywords: chick, K⁺-channel blocker, action potential duration

JOURNAL FREE ACCESS

2011 Volume 115 Issue 2 Pages 235-238

DOI https://doi.org/10.1254/jphs.10205SC

View "Advance Publication" version (January 20, 2011).

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Abstract

The effects of K⁺-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 – 10-day-old, 11 – 13-day-old, and 14 – 20-day-old embryo and 1 – 7-day-old hatched chicks. E-4031 significantly prolonged action potential duration at all developmental stages examined; the prolongation was largest in the 11 – 13-day-old embryo and was accompanied by early after-depolarizations. Chromanol 293B showed smaller prolongation at all stages examined. Terfenadine prolonged action potential duration in the 11 – 13-day-old embryo, but not in other stages. Thus, the chick ventricular myocardium changes its repolarization properties during development.

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