1952 Volume 1 Issue 2 Pages 87-90
It is well known that some of the antihistaminic drug such as diphenhydramine has marked hypnotic action. The mechanism of this action is, however, remained obscure for it acts in experimental animal not as a central depressant but rather as a central stimulant. An attempt was made, therefore, to compare the effect of this drug upon the electroencephalogram (EEG) of man with that of rabbit.