Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Population Science
Concomitant Mitral Regurgitation in Severe Aortic Stenosis　― A Report From the CURRENT AS Registry ―
Ryosuke Murai, Yuichi Kawase, Tomohiko Taniguchi, Takeshi Morimoto, Kazushige Kadota, Masanobu Ohya, Takenobu Shimada, Takeshi Maruo, Yasushi Fuku, Tatsuhiko Komiya, Kenji Ando, Michiya Hanyu, Norio Kanamori, Takeshi Aoyama, Koichiro Murata, Tomoya Onodera, Fumio Yamazaki, Takeshi Kitai, Yutaka Furukawa, Tadaaki Koyama, Makoto Miyake, Chisato Izumi, Yoshihisa Nakagawa, Kazuo Yamanaka, Hirokazu Mitsuoka, Manabu Shirotani, Masashi Kato, Shinji Miki, Hiroyuki Nakajima, Yutaka Hirano, Shunichi Miyazaki, Toshihiko Saga, Sachiko Sugioka, Shintaro Matsuda, Mitsuo Matsuda, Tatsuya Ogawa, Kazuya Nagao, Tsukasa Inada, Shogo Nakayama, Hiroshi Mabuchi, Yasuyo Takeuchi, Hiroki Sakamoto, Genichi Sakaguchi, Keiichiro Yamane, Hiroshi Eizawa, Mamoru Toyofuku, Takashi Tamura, Atsushi Iwakura, Mitsuru Ishii, Masaharu Akao, Kotaro Shiraga, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Koji Ueyama, Tomoyuki Ikeda, Yoshihiro Himura, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Yukihito Sato, Keiichi Fujiwara, Yoshihiro Kato, Ichiro Kouchi, Yasutaka Inuzuka, Shigeru Ikeguchi, Senri Miwa, Chiyo Maeda, Eiji Shinoda, Junichiro Nishizawa, Toshikazu Jinnai, Nobuya Higashitani, Mitsuru Kitano, Yuko Morikami, Shouji Kitaguchi, Kenji Minatoya, Takeshi Kimura, on behalf of the CURRENT AS Registry Investigators
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Keywords: Aortic stenosis, Aortic valve replacement, Mitral regurgitation
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2022 Volume 86 Issue 3 Pages 427-437

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Editorial (86-3 pp. 438-439)
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Abstract

Background:The clinical significance of concomitant mitral regurgitation (MR) has not been well addressed in patients with severe aortic stenosis (AS).

Methods and Results:We analyzed 3,815 patients from a retrospective multicenter registry of severe AS in Japan (CURRENT AS registry). We compared the clinical outcomes between patients with moderate/severe MR and with none/mild MR according to the initial treatment strategy (initial aortic valve replacement [AVR] or conservative strategy). The primary outcome measure was a composite of aortic valve-related death or heart failure hospitalization. At baseline, moderate/severe MR was present in 227/1,197 (19%) patients with initial AVR strategy and in 536/2,618 (20%) patients with a conservative strategy. The crude cumulative 5-year incidence of the primary outcome measure was significantly higher in patients with moderate/severe MR than in those with none/mild MR, regardless of the initial treatment strategy (25.2% vs. 14.4%, P<0.001 in the initial AVR strategy, and 63.3% vs. 40.7%, P<0.001 in the conservative strategy). After adjusting confounders, moderate/severe MR was not independently associated with higher risk for the primary outcome measure in the initial AVR strategy (hazard ratio [HR] 1.11, 95% confidence interval [CI] 0.67–1.83, P=0.69), and in the conservative strategy (HR 1.13, 95% CI 0.93–1.37, P=0.22).

Conclusions:Concomitant moderate/severe MR was not independently associated with higher risk for the primary outcome measure regardless of the initial treatment strategy.

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© 2022, THE JAPANESE CIRCULATION SOCIETY

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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