Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms

Deborah A. Howatt; Maya Dajee; Xiaojie Xie; Jessica Moorleghen; Debra L. Rateri; Anju Balakrishnan; Valdeci Da Cunha; Douglas G. Johns; David E. Gutstein; Alan Daugherty; Hong Lu

doi:10.1253/circj.CJ-17-0229

Rapid Communication

Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms

Deborah A. Howatt, Maya Dajee, Xiaojie Xie, Jessica Moorleghen, Debra L. Rateri, Anju Balakrishnan, Valdeci Da Cunha, Douglas G. Johns, David E. Gutstein, Alan Daugherty, Hong Lu

Author information

Deborah A. Howatt
Saha Cardiovascular Research Center, University of Kentucky
Maya Dajee
Cardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Xiaojie Xie
Saha Cardiovascular Research Center, University of Kentucky
Cardiovascular Key Laboratory of Zhejiang Province, Department of Cardiology, Second Affiliated Hospital, Zhejiang University College of Medicine
Jessica Moorleghen
Saha Cardiovascular Research Center, University of Kentucky
Debra L. Rateri
Saha Cardiovascular Research Center, University of Kentucky
Anju Balakrishnan
Saha Cardiovascular Research Center, University of Kentucky
Valdeci Da Cunha
Cardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Douglas G. Johns
Cardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
David E. Gutstein
Cardio-Metabolic Diseases, Merck Research Laboratories, Cardiovascular Research Center, Merck & Co., Inc.
Alan Daugherty
Saha Cardiovascular Research Center, University of Kentucky
Department of Physiology, University of Kentucky
Hong Lu
Saha Cardiovascular Research Center, University of Kentucky
Department of Physiology, University of Kentucky

Keywords: Abdominal aortic aneurysm, Matrix metalloproteinase, Relaxin

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Supplementary material

2017 Volume 81 Issue 6 Pages 888-890

DOI https://doi.org/10.1253/circj.CJ-17-0229

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Abstract

Background:This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).

Methods and Results:Male C57BL/6 or apolipoprotein E^−/−mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E^−/−mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.

Conclusions:MMP-9 deficiency augmented AngII-induced AAA.

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