Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein

Akira Takashima; Takayuki Ise; Shusuke Yagi; Takashi Iwase; Sahika Kimura; Yuka Ueda; Koji Nishikawa; Ayumi Ishii; Toshiyuki Niki; Koji Yamaguchi; Yoshio Taketani; Hirotsugu Yamada; Takeshi Soeki; Tetsuzo Wakatsuki; Shinsuke Katoh; Masashi Akaike; Masataka Sata

doi:10.1253/circj.CJ-14-0532

Cardiac Rehabilitation

Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein

Akira Takashima, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Sahika Kimura, Yuka Ueda, Koji Nishikawa, Ayumi Ishii, Toshiyuki Niki, Koji Yamaguchi, Yoshio Taketani, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Shinsuke Katoh, Masashi Akaike, Masataka Sata

Author information

Akira Takashima
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Takayuki Ise
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Shusuke Yagi
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Takashi Iwase
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Sahika Kimura
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Yuka Ueda
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Koji Nishikawa
Department of Rehabilitation, Tokushima University Hospital
Ayumi Ishii
Department of Rehabilitation, Tokushima University Hospital
Toshiyuki Niki
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Koji Yamaguchi
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Yoshio Taketani
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Hirotsugu Yamada
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Takeshi Soeki
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Tetsuzo Wakatsuki
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Shinsuke Katoh
Department of Rehabilitation, Tokushima University Hospital
Masashi Akaike
Department of Medical Education, Institute of Health Biosciences, The University of Tokushima Graduate School
Masataka Sata
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School

Keywords: Cardiac rehabilitation, Lipoproteins, Oxidative stress

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2014 Volume 78 Issue 11 Pages 2682-2687

DOI https://doi.org/10.1253/circj.CJ-14-0532

Editorial (78-11 pp.2624-2626)

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Abstract

Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O₂) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O₂increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. ∆V̇O₂(peak V̇O₂after CR–peak V̇O₂before CR) was negatively associated with ∆MDA-LDL (MDA-LDL after CR–MDA-LDL before CR) (R²=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.Conclusions:CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682–2687)

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