Alkylated Benzoquinones: Ardisiaquinones A–H from the Leaves of Ardisia quinquegona and Their Anti-Leishmania Activity

Shintaro Asaumi; Susumu Kawakami; Sachiko Sugimoto; Katsuyoshi Matsunami; Hideaki Otsuka; Takakazu Shinzato

doi:10.1248/cpb.c18-00281

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Alkylated Benzoquinones: Ardisiaquinones A–H from the Leaves of Ardisia quinquegona and Their Anti-Leishmania Activity

Shintaro Asaumi, Susumu Kawakami, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka , Takakazu Shinzato

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Keywords: Ardisia quinquegona, Primulaceae, alkylated benzoquinone, anti-Leishmania activity

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2018 Volume 66 Issue 7 Pages 757-763

DOI https://doi.org/10.1248/cpb.c18-00281

J-STAGE : cpb 67 1 pp.79-79

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Abstract

Eight alkylated benzoquinone derivatives, named ardisiaquinones A–H, were isolated together with four known compounds from the leaves of Ardisia quinquegona using a combination of different chromatography techniques. Their structures were elucidated by spectroscopy and by the preparation of methyl ethers. Anti-Leishmania activity and cytotoxicity of the isolated compounds were assayed. Some compounds showed moderate anti-Leishmania activity, however, always associated with cytotoxicity.

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