Synthesis of Dibenzofurans Directly from Aryl Halides and ortho-Bromophenols via One-Pot Consecutive S<small>N</small>Ar and Intramolecular Palladium-Catalyzed Aryl–Aryl Coupling Reactions

Hui Xu; Ling-Ling Fan

doi:10.1248/cpb.56.1496

Notes

Synthesis of Dibenzofurans Directly from Aryl Halides and ortho-Bromophenols via One-Pot Consecutive SNAr and Intramolecular Palladium-Catalyzed Aryl–Aryl Coupling Reactions

Hui Xu, Ling-Ling Fan

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Keywords: dibenzofuran, one-pot reaction, C(sp²)–O bond formation reaction, aryl–aryl coupling reaction

JOURNAL FREE ACCESS

2008 Volume 56 Issue 10 Pages 1496-1498

DOI https://doi.org/10.1248/cpb.56.1496

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Abstract

A series of dibenzofurans were efficiently and conveniently synthesized via one-pot consecutive C(sp²)–O bond formation reaction (SNAr) in the presence of anhydrous K₂CO₃, followed by C(sp²)–C(sp²) bond formation reaction (intramolecular palladium-catalyzed aryl–aryl coupling reaction) between aryl halides and ortho-bromophenols. The desired dibenzofurans were obtained in 32—99% isolated yields.

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