Limonoids from the Root of Dictamnus radicis Cortex

Pei Hua Zhao; Li Mei Sun; Xiu Jin Liu; Mei Ai Cao; Cheng Shan Yuan

doi:10.1248/cpb.56.102

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Limonoids from the Root of Dictamnus radicis Cortex

Pei Hua Zhao, Li Mei Sun, Xiu Jin Liu, Mei Ai Cao, Cheng Shan Yuan

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Keywords: Dictamnus radicis Cortex, isodictamdiol, absolute configuration, antibacterial activity

JOURNAL FREE ACCESS

2008 Volume 56 Issue 1 Pages 102-104

DOI https://doi.org/10.1248/cpb.56.102

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Abstract

Chemical investigation of the roots of Dictamnus radicis Cortex led to the isolation of a new limonoid isodictamdiol (1) and a known dictamdiol (2), the first 5S/9S-type degraded limonoids, together with other six known limonoids (3—8). The chemical structures were identified on the basis of modern spectroscopic methods, including IR, MS, NMR (¹H-NMR, ¹³C-NMR, ¹H–¹H COSY, HMQC, HMBC, NOESY). Additionally, the absolute configurations of limonoid isodictamdiol (1) and dictamdiol (2) were separately elucidated by single crystal X-ray diffraction, as well as their circular dichroism spectra. Furthermore, all compounds were evaluated for antibacterial activity against three bacterial cultures.

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