Cytotoxic Limonoids from Brazilian Melia azedarach

Honglei Zhou; Atsuko Hamazaki; Jose Domingos Fontana; Hironobu Takahashi; Carolina Bueno Wandscheer; Yoshiyasu Fukuyama

doi:10.1248/cpb.53.1362

Notes

Cytotoxic Limonoids from Brazilian Melia azedarach

Honglei Zhou, Atsuko Hamazaki, Jose Domingos Fontana, Hironobu Takahashi, Carolina Bueno Wandscheer, Yoshiyasu Fukuyama

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Keywords: tetranortriterpenoid, limonoid, Melia azedarach, cytotoxicity

JOURNAL FREE ACCESS

2005 Volume 53 Issue 10 Pages 1362-1365

DOI https://doi.org/10.1248/cpb.53.1362

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Abstract

Three new C-seco limonoids (1—3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.

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