Indonesian Medicinal Plants. XXV. Cancer Cell Invasion Inhibitory Effects of Chemical Constituents in the Parasitic Plant Scurrula atropurpurea (Loranthaceae)

Kazuyoshi Ohashi; Hendig Winarno; Mutsuko Mukai; Masahiro Inoue; Made Sri Prana; Partomuan Simanjuntak; Hirotaka Shibuya

doi:10.1248/cpb.51.343

Notes

Indonesian Medicinal Plants. XXV. Cancer Cell Invasion Inhibitory Effects of Chemical Constituents in the Parasitic Plant Scurrula atropurpurea (Loranthaceae)

Kazuyoshi Ohashi, Hendig Winarno, Mutsuko Mukai, Masahiro Inoue, Made Sri Prana, Partomuan Simanjuntak, Hirotaka Shibuya

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Keywords: Scurrula atropurpurea, cancer cell invasion inhibition, octadeca-8,10,12-triynoic acid, catechin, Loranthaceae

JOURNAL FREE ACCESS

2003 Volume 51 Issue 3 Pages 343-345

DOI https://doi.org/10.1248/cpb.51.343

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Abstract

Six fatty acids (1—6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13—16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-triynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (−)-epicatechin (14), (−)-epicatechin-3-O-gallate (15) and (−)-epigallocatechin-3-O-gallate (16)].

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