Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.

Motomasa KOBAYASHI; Yin-Ju CHEN; Kouichi HIGUCHI; Shunji AOKI; Isao KITAGAWA

doi:10.1248/cpb.44.1840

Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.

Motomasa KOBAYASHI, Yin-Ju CHEN, Kouichi HIGUCHI, Shunji AOKI, Isao KITAGAWA

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Keywords: marine sponge, Xestospongia, steroid, cytotoxic, dimethylketal

JOURNAL FREE ACCESS

1996 Volume 44 Issue 10 Pages 1840-1842

DOI https://doi.org/10.1248/cpb.44.1840

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Abstract

Aragusteroketals A (1) and C (2), two new marine steroids having dimethylketal structure, were isolated from an Okinawan marine sponge of Xestospongia sp. The chemical structures of 1 and 2 were determined on the basis of spectroscopic analysis and chemical evidence. Compounds 1 and 2 showed potent cytotoxic activity with the same IC₅₀ value of 4 ng/ml against KB cells.

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