CORRELATION OF OCTANOL-WATER PARTITION COEFFICIENTS WITH CAPACITY FACTORS MEASURED BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY

Yasushi ISHIHAMA; Yoshiya ODA; Kiyohiko UCHIKAWA; Naoki ASAKAWA

doi:10.1248/cpb.42.1525

Yasushi ISHIHAMA, Yoshiya ODA, Kiyohiko UCHIKAWA, Naoki ASAKAWA

Author information

Keywords: micellar electrokinetic chromatography, hydrophobicity, capacity factor, partition coefficient, octanol-water

JOURNAL FREE ACCESS

1994 Volume 42 Issue 7 Pages 1525-1527

DOI https://doi.org/10.1248/cpb.42.1525

Details

Abstract

Micellar electrokinetic chromatography (MEKC) was used to measure hydrophobicity of 18 aromatic compounds. The capacity factors, which are proportional to the micelle-water distribution coefficients, were closely correlated with the octanol-water partition coefficients. The addition of Brij 35 to the charged micelle was effective in improving the correlation because the surface charges of the micelle were shielded.

Corresponding author

Register with J-STAGE for free!