Synthesis and Antitumor Activity of Fused Quinoline Derivatives. III. Novel N-Glycosylamino-indolo[3, 2-b]quinolines

Yasuo TAKEUCHI; Ming-rong CHANG; Kuniko HASHIGAKI; Tazuko TASHIRO; Takashi TSURUO; Shigeru TSUKAGOSHI; Masatoshi YAMATO

doi:10.1248/cpb.40.1481

Yasuo TAKEUCHI, Ming-rong CHANG, Kuniko HASHIGAKI, Tazuko TASHIRO, Takashi TSURUO, Shigeru TSUKAGOSHI, Masatoshi YAMATO

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Keywords: indolo[3, 2-b]quinoline, glycosylation, antitumor activity, P388 leukemia

JOURNAL FREE ACCESS

1992 Volume 40 Issue 6 Pages 1481-1485

DOI https://doi.org/10.1248/cpb.40.1481

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Abstract

Novel indolo[3, 2-b]quinolines (1b-k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (1g) showed the most potent activity (optimal dose=25mg/kg, T/C>333%, cure rate 5/6).

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