Studies on Uricosuric Diuretics. III. Substituted 1, 3-Dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic Acids and 1, 3-Dioxolo[4, 5-g]-1, 2-benzisoxazole-7-carboxylic Acids

Haruhiko SATO; Takashi DAN; Etsuro ONUMA; Haruko TANAKA; Bunya AOKI; Hiroshi KOGA

doi:10.1248/cpb.40.109

Haruhiko SATO, Takashi DAN, Etsuro ONUMA, Haruko TANAKA, Bunya AOKI, Hiroshi KOGA

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Keywords: diuretic activity, uricosuric activity, 1, 3-dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic acid, 1, 3-dioxolo[4, 5-g]-1, 2-benzisoxazole-7-carboxylic acid

JOURNAL FREE ACCESS

1992 Volume 40 Issue 1 Pages 109-116

DOI https://doi.org/10.1248/cpb.40.109

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Abstract

A series of substituted 1, 3-dioxolo[4, 5-f]-1, 2-benzisoxazole-6-carboxylic acids 13 and 1, 3-dioxolo[4, 5-g]-1, 2-benzisozazole-7-carboxylic acids 14 were synthesized and evaluated for diuretic and uricosuric activities in rats. Most of the benzisoxazole derivatives 13 and 14 showed potent diuretic activities. Moderate uricosuric activities were also found in 14a, 14b, and 14f.

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