1980 Volume 28 Issue 7 Pages 2221-2225
The effects of the particle size of sulfadimethoxine on its in vitro and in vivo dissolution rates and on bioavailability were examined using rabbits. The particle size significantly affected the rate and extent of bioavailability, and the in vivo dissolution, which was calculated by the deconvolution method. A good correlaion between in vitro and in vivo dissolution rates was obtained.