Synthesis and Activity of C-Terminal Heptapeptides of Tachykinins and Bombesin-like Peptides

KOUKI KITAGAWA; KAZUKO UJITA; YOSHIAKI KISO; TADASHI AKITA; YOSHIHIRO NAKATA; NORIMASA NAKAMOTO; TOMIO SEGAWA; HARUAKI YAJIMA

doi:10.1248/cpb.27.48

KOUKI KITAGAWA, KAZUKO UJITA, YOSHIAKI KISO, TADASHI AKITA, YOSHIHIRO NAKATA, NORIMASA NAKAMOTO, TOMIO SEGAWA, HARUAKI YAJIMA

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Keywords: Methanesulfonic acid deprotection

JOURNAL FREE ACCESS

1979 Volume 27 Issue 1 Pages 48-57

DOI https://doi.org/10.1248/cpb.27.48

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Abstract

Five heptapeptide amides related to the C-terminal portion of tachykinins and two heptapeptide amides related to the C-terminal portion of bombesin-like peptides were synthesized and the smooth muscle contractile activity of these peptides was compared with that of the C-terminal heptapeptide of substance P by taking synthetic substance P as a standard.

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