Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Anti-Platelet Aggregation Activity of Some Pyrazines
Akihiro OHTA, Hiromitsu TAKAHASHI, Naoomi MIYATA, Hiroyuki HIRONO, Toyotaka NISHIO, Etsuo UCHINO, Kenji YAMADA, Yutaka AOYAGI, Yasushi SUWABE, Masayuki FUJITAKE, Takahiro SUZUKI, Kazuo OKAMOTO
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Keywords: alkylpyrazine, arylpyrazine, anti-platelet aggregation, rabbit PRP, 2, 3-bis(p-methoxyphenyl)pyrazine
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1997 Volume 20 Issue 10 Pages 1076-1081

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Abstract

This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl- and arylpyrazines tested, 2, 3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2, 3-bis(p-methoxyphenyl)pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.

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© The Pharmaceutical Society of Japan
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