Synthesis and Antihyperglycemic Activity of Erythrose, Ribose and Substituted Pyrrolidine Containing Thiazolidinedione Derivatives

Bok Young Kim; Joong Bok Ahn; Hong Woo Lee; Kyoung Sik Moon; Tae Bo Sim; Jae Soo Shin; Soon Kil Ahn; Chung Il Hong

doi:10.1248/cpb.51.276

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Synthesis and Antihyperglycemic Activity of Erythrose, Ribose and Substituted Pyrrolidine Containing Thiazolidinedione Derivatives

Bok Young Kim, Joong Bok Ahn, Hong Woo Lee, Kyoung Sik Moon, Tae Bo Sim, Jae Soo Shin, Soon Kil Ahn, Chung Il Hong

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Keywords: erythrose, ribose, substituted pyrrolidine, thiazolidinedione, glucose utilization, insulin sensitizing agent

JOURNAL FREE ACCESS

2003 Volume 51 Issue 3 Pages 276-285

DOI https://doi.org/10.1248/cpb.51.276

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Abstract

A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-{4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene}thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.

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