Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
REVIEW
Vinexin, CAP/ponsin, ArgBP2: a Novel Adaptor Protein Family Regulating Cytoskeletal Organization and Signal Transduction
Noriyuki KiokaKazumitsu UedaTeruo Amachi
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JOURNAL FREE ACCESS

2002 Volume 27 Issue 1 Pages 1-7

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Abstract

Adaptor proteins, composed of two or more protein-protein interacting modules without enzymatic activity, regulate various cellular functions. Vinexin, CAP/ponsin, and ArgBP2 constitute a novel adaptor protein family. They have a novel conserved region homologous to the active peptide sorbin, as well as three SH3 (src homology 3) domains. A number of proteins binding to this adaptor family have been identified. There is accumulating evidence that this protein family regulates cell adhesion, cytoskeletal organization, and growth factor signaling. This review will summarize the structure and the function of proteins in this family.

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© 2002 by Japan Society for Cell Biology
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