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Usefulness of Mapping Biopsy in the Treatment of Penoscrotal Extramammary Paget’s Disease

  • Urologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Extramammary Paget’s disease (EMPD) is a rare cutaneous malignancy; however, the standard treatment of EMPD has not been established. In this study, we applied mapping biopsy to penoscrotal EMPD and evaluated its effects.

Methods

A retrospective chart review was performed to determine the outcomes of patients with primary penoscrotal EMPD who underwent surgery at our institution between 2007 and 2014. Patients were divided into two groups (one group underwent mapping biopsy, while the other group did not), and the difference between the two groups was analyzed. The 5-year tumor-free rate was estimated using the Kaplan–Meier method, and the risk factors for local recurrence were also estimated.

Results

A total of 44 patients were analyzed, and the mean follow-up of patients was 50.27 months. Patients who underwent mapping biopsy showed significantly lower tumor involvement at permanent and frozen biopsies and a lower local recurrence rate than those who did not undergo mapping biopsy. The 5-year tumor-free rate was significantly higher in the mapping biopsy group than in the non-mapping biopsy group. Multivariable analysis demonstrated that age at operation, mapping biopsy, and false-negative results at frozen biopsy were associated with local recurrence.

Conclusions

Mapping biopsy is beneficial to reduce local recurrence in penoscrotal EMPD.

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Disclosure

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Research Institute of Plastic and Reconstructive Surgery, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea

    Seong Oh Park MD, Jeong Hyun Ha MD & Hak Chang MD, PhD

  2. Department of Plastic and Reconstructive Surgery, Dongguk University Medical Center, Goyang, Korea

    Ki Yong Hong MD, PhD

Authors
  1. Seong Oh Park MD
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  2. Jeong Hyun Ha MD
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  3. Ki Yong Hong MD, PhD
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  4. Hak Chang MD, PhD
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Corresponding author

Correspondence to Hak Chang MD, PhD.

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Park, S.O., Ha, J.H., Hong, K.Y. et al. Usefulness of Mapping Biopsy in the Treatment of Penoscrotal Extramammary Paget’s Disease. Ann Surg Oncol 24, 3229–3236 (2017). https://doi.org/10.1245/s10434-017-5947-7

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  • DOI: https://doi.org/10.1245/s10434-017-5947-7

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