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Effects of Genomic Changes in Hepatitis B Virus on Postoperative Recurrence and Survival in Patients with Hepatocellular Carcinoma

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether the genomic changes in hepatitis B virus (HBV) affect the clinical outcomes of hepatocellular carcinoma (HCC) in patients with HBV-associated HCC treated with curative surgical resection.

Methods

A total of 247 patients with HBV-associated HCC were treated with curative surgical resection. They were followed regularly for a median of 30 months. The whole X, S, basal core promoter (BCP), and precore regions of HBV were sequenced.

Results

The genomic changes such as the G1896A at precore, the A1762T/G1764A at BCP, the C1653T and the T1753V at X gene, and pre-S2 deletion were not significantly associated with postoperative recurrence of HCC or survival of patients after curative resection. However, in univariate analysis, younger age, elevated serum α-fetoprotein level, elevated serum alanine aminotransferase level, larger tumor size, microvascular invasion, and advanced Cancer of the Liver Italian Program stage were closely associated with shorter survival after surgical resection. In multivariate analysis, only microvascular invasion revealed to be an independent risk factor of postoperative recurrence (relative risk [RR] 5.406; P < 0.001); the independent risk factors of shorter survival appeared to be infiltrative type (RR 5.110; P = 0.032), larger tumor size (RR 1.976; P = 0.047), and microvascular invasion (RR 6.118; P < 0.001).

Conclusions

The postoperative recurrence or survival period may not be affected by the genomic changes at the precore, BCP, X, and pre-S2 regions in HBV of genotype C2 in patients with HBV-associated HCC treated with curative surgical resection. Rather, it may be closely associated with tumor characteristics, such as the size and type of HCC or presence of microvascular invasion.

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Authors and Affiliations

  1. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Priya Mathews, Heather Lyu, Elizabeth Jaffee MD & Lei Zheng MD

  2. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Danbi Lee MD, PhD, Young-Hwa Chung MD, PhD, Jeong A. Kim MS, Ju-Ho Lee MD, PhD, Young-Joo Jin MD & Wonhyung Park MD

  3. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Eunsil Yu MD, PhD

  4. Department of Hepatobiliary Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Young Joo Lee MD, PhD

Authors
  1. Priya Mathews
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  2. Danbi Lee MD, PhD
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  3. Young-Hwa Chung MD, PhD
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  4. Jeong A. Kim MS
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  5. Ju-Ho Lee MD, PhD
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  6. Young-Joo Jin MD
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  7. Wonhyung Park MD
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  8. Heather Lyu
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  9. Elizabeth Jaffee MD
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  10. Lei Zheng MD
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  11. Eunsil Yu MD, PhD
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  12. Young Joo Lee MD, PhD
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Corresponding author

Correspondence to Young-Hwa Chung MD, PhD.

Additional information

The first two authors contributed equally to this article, and both should be considered first author.

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Mathews, P., Lee, D., Chung, YH. et al. Effects of Genomic Changes in Hepatitis B Virus on Postoperative Recurrence and Survival in Patients with Hepatocellular Carcinoma. Ann Surg Oncol 20, 1216–1222 (2013). https://doi.org/10.1245/s10434-012-2706-7

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  • DOI: https://doi.org/10.1245/s10434-012-2706-7

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