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Selection of Patients for Resection of Hepatic Colorectal Metastases: Expert Consensus Statement

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References

  1. Choti MA, Sitzmann JV, Tiburi MF, et al. Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 2002;235:759–66

    Article  PubMed  Google Scholar 

  2. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004;239:818–25

    Article  PubMed  Google Scholar 

  3. Bipat S, van Leeuwen MS, Comans EF, et al. Colorectal liver metastases: CT, MR imaging, and PET for diagnosis—meta-analysis. Radiology 2005;237:123–31

    Article  PubMed  Google Scholar 

  4. Kinkel K, Lu Y, Both M, et al. Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis. Radiology 2002;224:748–56

    Article  PubMed  Google Scholar 

  5. Kamel IR, Choti MA, Horton KM, et al. Surgically staged focal liver lesions: accuracy and reproducibility of dual-phase helical CT for detection and characterization. Radiology 2003;227:752–7

    Article  PubMed  Google Scholar 

  6. Kim MJ, Kim JH, Chung JJ, et al. Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology 2003;228:719–26

    Article  PubMed  Google Scholar 

  7. del Frate C, Bazzocchi M, Mortele KJ, et al. Detection of liver metastases: comparison of gadobenate dimeglumine-enhanced and ferumoxides-enhanced MR imaging examinations. Radiology 2002;225:766–72

    Article  PubMed  Google Scholar 

  8. Ward J, Guthrie JA, Wilson D, et al. Colorectal hepatic metastases: detection with SPIO-enhanced breath-hold MR imaging—comparison of optimized sequences. Radiology 2003;228:709–18

    Article  PubMed  Google Scholar 

  9. Huebner RH, Park KC, Shepherd JE, et al. A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer. J Nucl Med 2000;41:1177–89

    CAS  PubMed  Google Scholar 

  10. Selzner M, Hany TF, Wildbrett P, et al. Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver? Ann Surg 2004;240:1027–34

    Article  PubMed  Google Scholar 

  11. Downey RJ, Akhurst T, Gonen M, et al. Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection. J Clin Oncol 2004;22:3255–60

    Article  PubMed  Google Scholar 

  12. Downey RJ, Akhurst T, Ilson D, et al. Whole body 18FDG-PET and the response of esophageal cancer to induction therapy: results of a prospective trial. J Clin Oncol 2003;21:428–32

    Article  PubMed  Google Scholar 

  13. Jarnagin WR, Fong Y, Ky A, et al. Liver resection for metastatic colorectal cancer: assessing the risk of occult irresectable disease. J Am Coll Surg 1999;188:33–42

    Article  CAS  PubMed  Google Scholar 

  14. Fong Y, Saldinger PF, Akhurst T, et al. Utility of 18F-FDG positron emission tomography scanning on selection of patients for resection of hepatic colorectal metastases. Am J Surg 1999;178:282–7

    Article  CAS  PubMed  Google Scholar 

  15. Fernandez FG, Drebin JA, Linehan DC, et al. Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET). Ann Surg 2004;240:438–47

    Article  PubMed  Google Scholar 

  16. Joyce DL, Wahl RL, Patel PV, et al. Preoperative PET to evaluate potentially resectable hepatic colorectal metastases. Arch Surg 2006 (in press)

  17. Nordlinger B, Quilichini MA, Parc R, et al. Hepatic resection for colorectal liver metastases. Influence on survival of preoperative factors and surgery for recurrences in 80 patients. Ann Surg 1987;205:256–63

    Article  CAS  PubMed  Google Scholar 

  18. Schlag P, Hohenberger P, Herfarth C. Resection of liver metastases in colorectal cancer—competitive analysis of treatment results in synchronous versus metachronous metastases. Eur J Surg Oncol 1990;16:360–5

    CAS  PubMed  Google Scholar 

  19. Scheele J, Stangl R, Altendorf-Hofmann A, Gall FP. Indicators of prognosis after hepatic resection for colorectal secondaries. Surgery 1991;110:13–29

    CAS  PubMed  Google Scholar 

  20. Iwatsuki S, Shaw BW, Jr., Starzl TE. Experience with 150 liver resections. Ann Surg 1983;197:247–53

    Article  CAS  PubMed  Google Scholar 

  21. Vauthey JN, Pawlik TM, Abdalla EK, et al. Is extended hepatectomy for hepatobiliary malignancy justified? Ann Surg 2004;239:722–32

    Article  PubMed  Google Scholar 

  22. Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999;230:309–18

    Article  CAS  PubMed  Google Scholar 

  23. Iwatsuki S, Dvorchik I, Madariaga JR, et al. Hepatic resection for metastatic colorectal adenocarcinoma: a proposal of a prognostic scoring system. J Am Coll Surg 1999;189:291–9

    Article  CAS  PubMed  Google Scholar 

  24. Nordlinger B, Guiguet M, Vaillant JC, et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer 1996;77:1254–62

    Article  CAS  PubMed  Google Scholar 

  25. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 1999;341:2039–48

    Article  CAS  PubMed  Google Scholar 

  26. Adson MA. Resection of liver metastases—when is it worthwhile? World J Surg 1987;11:511–20

    Article  CAS  PubMed  Google Scholar 

  27. Holm A, Bradley E, Aldrete JS. Hepatic resection of metastasis from colorectal carcinoma. Morbidity, mortality, and pattern of recurrence. Ann Surg 1989;209:428–34

    Article  CAS  PubMed  Google Scholar 

  28. Doci R, Gennari L, Bignami P, et al. One hundred patients with hepatic metastases from colorectal cancer treated by resection: analysis of prognostic determinants. Br J Surg 1991;78:797–801

    Article  CAS  PubMed  Google Scholar 

  29. Hughes KS, Simon R, Songhorabodi S, et al. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery 1986;100:278–84

    CAS  PubMed  Google Scholar 

  30. Hughes K, Scheele J, Sugarbaker PH. Surgery for colorectal cancer metastatic to the liver. Optimizing the results of treatment. Surg Clin North Am 1989;69:339–59

    CAS  PubMed  Google Scholar 

  31. Ballantyne GH, Quin J. Surgical treatment of liver metastases in patients with colorectal cancer. Cancer 1993;71:4252–66

    Article  CAS  PubMed  Google Scholar 

  32. Rosen CB, Nagorney DM, Taswell HF, et al. Perioperative blood transfusion and determinants of survival after liver resection for metastatic colorectal carcinoma. Ann Surg 1992;216:493–504

    Article  CAS  PubMed  Google Scholar 

  33. Ekberg H, Tranberg KG, Andersson R, et al. Pattern of recurrence in liver resection for colorectal secondaries. World J Surg 1987;11:541–7

    Article  CAS  PubMed  Google Scholar 

  34. Stephenson KR, Steinberg SM, Hughes KS, et al. Perioperative blood ransfusions are associated with decreased time to recurrence and decreased survival after resection of colorectal liver metastases. Ann Surg 1988;208:679–87

    Article  CAS  PubMed  Google Scholar 

  35. DeMatteo RP, Palese C, Jarnagin WR, et al. Anatomic segmental hepatic resection is superior to wedge resection as an oncologic operation for colorectal liver metastases. J Gastrointest Surg 2000;4:178–84

    Article  CAS  PubMed  Google Scholar 

  36. Cady B, McDermott WV. Major hepatic resection for metachronous metastases from colon cancer. Ann Surg 1985;201:204–9

    Article  CAS  PubMed  Google Scholar 

  37. Fortner JG, Silva JS, Cox EB, et al. Multivariate analysis of a personal series of 247 patients with liver metastases from colorectal cancer. II. Treatment by intrahepatic chemotherapy. Ann Surg 1984;199:317–24

    Article  CAS  PubMed  Google Scholar 

  38. Adson MA, van Heerden JA, Adson MH, et al. Resection of hepatic metastases from colorectal cancer. Arch Surg 1984;119:647–51

    CAS  PubMed  Google Scholar 

  39. Gayowski TJ, Iwatsuki S, Madariaga JR, et al. Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery 1994;116:703–10

    CAS  PubMed  Google Scholar 

  40. Scheele J, Rudroff C, Altendorf-Hofmann A. Resection of colorectal liver metastases revisited. J Gastrointest Surg 1997;1:408–22

    Article  CAS  PubMed  Google Scholar 

  41. Cady B, Stone MD. The role of surgical resection of liver metastases in colorectal carcinoma. Semin Oncol 1991;18:399–406

    CAS  PubMed  Google Scholar 

  42. Mala T, Bohler G, Mathisen O, et al. Hepatic resection for colorectal metastases: can preoperative scoring predict patient outcome? World J Surg 2002;26:1348–53

    Article  PubMed  Google Scholar 

  43. Schussler-Fiorenza CM, Mahvi DM, Niederhuber J, et al. Clinical risk score correlates with yield of PET scan in patients with colorectal hepatic metastases. J Gastrointest Surg 2004;8:150–7

    Article  PubMed  Google Scholar 

  44. Jarnagin WR, Conlon K, Bodniewicz J, et al. A clinical scoring system predicts the yield of diagnostic laparoscopy in patients with potentially resectable hepatic colorectal metastases. Cancer 2001;91:1121–8

    Article  CAS  PubMed  Google Scholar 

  45. Chen YT, Henk MJ, Carney KJ, et al. Prognostic Significance of Tumor Markers in Colorectal Cancer Patients: DNA Index, S-Phase Fraction, p53 Expression, and Ki-67 Index. J Gastrointest Surg 1997;1:266–73

    Article  CAS  PubMed  Google Scholar 

  46. Domont J, Pawlik TM, Boige V, et al. Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis. J Clin Oncol 2005;23:3086–93

    Article  CAS  PubMed  Google Scholar 

  47. Banerjee D, Gorlick R, Liefshitz A, et al. Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res 2000;60:2365–7

    CAS  PubMed  Google Scholar 

  48. Gonen M, Hummer A, Zervoudakis A, et al. Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer. J Clin Oncol 2003;21:406–12

    Article  CAS  PubMed  Google Scholar 

  49. Park DJ, Stoehlmacher J, Lenz HJ. Tailoring chemotherapy in advanced colorectal cancer. Curr Opin Pharmacol 2003;3:378–85

    Article  CAS  PubMed  Google Scholar 

  50. Gorlick R, Metzger R, Danenberg KD, et al. Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma. J Clin Oncol 1998;16:1465–9

    CAS  PubMed  Google Scholar 

  51. Allen PJ, Kemeny N, Jarnagin W, et al. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 2003;7:109–17

    Article  PubMed  Google Scholar 

  52. Adam R, Avisar E, Ariche A, et al. Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal [liver] metastases. Ann Surg Oncol 2001;8:347–53

    Article  CAS  PubMed  Google Scholar 

  53. Jenkins LT, Millikan KW, Bines SD, et al. Hepatic resection for metastatic colorectal cancer. Am Surg 1997;63:605–10

    CAS  PubMed  Google Scholar 

  54. Fujita S, Akasu T, Moriya Y. Resection of synchronous liver metastases from colorectal cancer. Jpn J Clin Oncol 2000;30:7–11

    Article  CAS  PubMed  Google Scholar 

  55. Elias D, Detroz B, Lasser P, et al. Is simultaneous hepatectomy and intestinal anastomosis safe? Am J Surg 1995;169:254–60

    Article  CAS  PubMed  Google Scholar 

  56. Chua HK, Sondenaa K, Tsiotos GG, et al. Concurrent vs. staged colectomy and hepatectomy for primary colorectal cancer with synchronous hepatic metastases. Dis Colon Rectum 2004;47:1310–6

    Article  PubMed  Google Scholar 

  57. Benoist S, Pautrat K, Mitry E, et al. Treatment strategy for patients with colorectal cancer and synchronous irresectable liver metastases. Br J Surg 2005;92:1155–60

    Article  CAS  PubMed  Google Scholar 

  58. Lyass S, Zamir G, Matot I, et al. Combined colon and hepatic resection for synchronous colorectal liver metastases. J Surg Oncol 2001;78:17–21

    Article  CAS  PubMed  Google Scholar 

  59. Martin R, Paty P, Fong Y, et al. Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastasis. J Am Coll Surg 2003;197:233–41

    Article  PubMed  Google Scholar 

  60. Jaeck D, Bachellier P, Nakano H, et al. One or two-stage hepatectomy combined with portal vein embolization for initially nonresectable colorectal liver metastases. Am J Surg 2003;185:221–9

    Article  PubMed  Google Scholar 

  61. Jaeck D, Oussoultzoglou E, Rosso E, et al. A two-stage hepatectomy procedure combined with portal vein embolization to achieve curative resection for initially unresectable multiple and bilobar colorectal liver metastases. Ann Surg 2004;240:1037–49

    Article  PubMed  Google Scholar 

  62. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 2005;241:715–24

    Article  PubMed  Google Scholar 

  63. Scheele J, Altendorf-Hofmann A, Grube T, et al. [Resection of colorectal liver metastases. What prognostic factors determine patient selection?]. Chirurg 2001;72:547–60

    Article  CAS  PubMed  Google Scholar 

  64. Ekberg H, Tranberg KG, Andersson R, et al. Determinants of survival in liver resection for colorectal secondaries. Br J Surg 1986;73:727–31

    Article  CAS  PubMed  Google Scholar 

  65. Cady B, Jenkins RL, Steele GD, Jr. et al. Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg 1998;227:566–71

    Article  CAS  PubMed  Google Scholar 

  66. Shirabe K, Takenaka K, Gion T, et al. Analysis of prognostic risk factors in hepatic resection for metastatic colorectal carcinoma with special reference to the surgical margin. Br J Surg 1997;84:1077–80

    Article  CAS  PubMed  Google Scholar 

  67. Fuhrman GM, Curley SA, Hohn DC, Roh MS. Improved survival after resection of colorectal liver metastases. Ann Surg Oncol 1995;2:537–41

    Article  CAS  PubMed  Google Scholar 

  68. Steele G Jr., Bleday R, Mayer RJ, et al. A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584. J Clin Oncol 1991;9:1105–12

    PubMed  Google Scholar 

  69. Altendorf-Hofmann A, Scheele J. A critical review of the major indicators of prognosis after resection of hepatic metastases from colorectal carcinoma. Surg Oncol Clin N Am 2003;12:165–92, xi

    Article  PubMed  Google Scholar 

  70. Abdalla EK, Barnett CC, Doherty D, et al. Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 2002;137:675–80

    Article  PubMed  Google Scholar 

  71. Abdalla EK, Hicks ME, Vauthey JN. Portal vein embolization: rationale, technique and future prospects. Br J Surg 2001;88:165–75

    Article  CAS  PubMed  Google Scholar 

  72. Elias D, Ouellet JF, Bellon N, et al. Extrahepatic disease does not contraindicate hepatectomy for colorectal liver metastases. Br J Surg 2003;90:567–74

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Michael A. Choti MD, MBA.

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Proceedings of the Consensus Conference sponsored by the American Hepato-Pancreato-Biliary Association and Co-Sponsored by The Society for Surgery of the Alimentary Tract and The Society of Surgical Oncology held in San Francisco, CA, January 25, 2006.

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Charnsangavej, C., Clary, B., Fong, Y. et al. Selection of Patients for Resection of Hepatic Colorectal Metastases: Expert Consensus Statement. Ann Surg Oncol 13, 1261–1268 (2006). https://doi.org/10.1245/s10434-006-9023-y

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