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Recurrence After Cystectomy for Borderline Ovarian Tumors: Results of a French Multicenter Study

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Abstract

Background

Fertility-sparing surgery for borderline ovarian tumors (BOT) is feasible and effective and does not seem to have a negative effect on survival. Specific data on the effect of cystectomy, and notably on recurrence, are lacking.

Methods

This was a French retrospective multicenter study of 313 women with stage I BOT treated from 1990 to 2000 in 13 specialized gynecological units and 1 cancer center. Diagnosis and staging were based on International Federation of Gynecology and Obstetrics (1989) criteria. Surgery consisted of cystectomy, unilateral salpingo-oophorectomy (USO), or bilateral salpingo-oophorectomy (BSO).

Results

After cystectomy, persistent BOT and benign ovarian cysts on the operated ovary were observed in 15% and 65% of patients, respectively. Mean follow-up did not differ among patients receiving the three types of surgery. The recurrences after cystectomy, USO, and BSO treatment were 30.3%, 11%, and 1.7%, respectively (P < .0001). Recurrences were more frequent after cystectomy than after USO (P = .0001) and BSO (P = .0001) and when intraoperative cyst rupture occurred (P = .04).

Conclusions

These results suggest that cystectomy for BOT is associated with a high risk of intraoperative cyst rupture and of recurrence compared with USO or BSO.

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Acknowledgments

The authors thank the following individuals for supplying materials for this study: Prof. Philippe Descamps, Centre Hospitalier Universitaire Angers, Angers, France; Dr. Eric Fondrinier, Centre de Recherche et de Lutte Contre le Cancer Paul Papin Angers, Angers, France; Dr. Philippe Pillot, Centre Hospitalier Général Le Mans, Le Mans, France; Prof. Denis Querleu, Centre Hospitalier Universitaire Lille, Lille, France; Prof. Bernard Blanc, Centre Hospitalier Universitaire Marseille, Marseille, France; Prof. Hervé Fernandez, Centres Hospitaliers Universitaires Paris, Hôpital Béclère, Clamart, France; Prof. Patrick Madelenat, Hôpital Bichat, Paris, France; Prof. Charles Chapron, Hôpital Cochin, Paris, France; Prof. Jean Blondon and Prof. Yves Darbois, Hôpital de la Pitié-Salpétrière, Paris, France; Prof. Jacques Milliez, Hôpital Saint-Antoine, Paris, France; and Prof. Serge Uzan, Hôpital Tenon, Paris, France.

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Authors and Affiliations

  1. Service de Gynécologie-Obstétrique, Hôpital Tenon, AP-HP, 4 Rue de la Chine, CancerEst, UFR Saint-Antoine, Paris VI, 75020, France

    Christophe Poncelet MD, PhD, Raffaèle Fauvet MD, Joëlle Boccara MD & Emile Daraï MD, PhD

  2. UFR SMBH Léonard De Vinci, Université Paris XIII, Bobigny Cedex, Paris, 93017, France

    Christophe Poncelet MD, PhD

Authors
  1. Christophe Poncelet MD, PhD
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  2. Raffaèle Fauvet MD
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  3. Joëlle Boccara MD
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  4. Emile Daraï MD, PhD
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Corresponding author

Correspondence to Emile Daraï MD, PhD.

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Poncelet, C., Fauvet, R., Boccara, J. et al. Recurrence After Cystectomy for Borderline Ovarian Tumors: Results of a French Multicenter Study. Ann Surg Oncol 13, 565–571 (2006). https://doi.org/10.1245/ASO.2006.12.024

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  • DOI: https://doi.org/10.1245/ASO.2006.12.024

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