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Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer

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Abstract

Background

The aim of this study was to evaluate the clinical and therapeutic value of digital fusion image (FI) of positron emission tomography (PET) using 18F-fluorodeoxy glucose and computed tomography (CT) in patients who were suspected of having a local recurrence of rectal cancer.

Methods

Forty-two patients (32 men and 10 women; mean age, 61.4 years, range, 40–79 years) with a suspicion of local recurrence after curative resection of rectal cancer were prospectively recruited and underwent 18F-fluorodeoxy glucose-PET and CT. The FI was reconstructed with a commercially available digital software program, T-B Fusion. Wilcoxon signed rank test was used to compare FI with CT alone or PET alone.

Results

FI yielded a correct diagnosis in 39 (93%) of 42 patients, whereas CT alone and PET alone did so in 33 (79%) and 37 (88%) patients, respectively. FI had better diagnostic accuracy than CT alone (P = .0138) and PET alone (P = .0156). Overall, FI altered patient management in 11 (26.2%) patients on the basis of additional information, including differentiation of the tumor from the postoperative scar in 6 patients, exact anatomical location in 3 patients, and both in 2 patients.

Conclusions

FI has a potential clinical value in the treatment of suspected local recurrence of rectal cancer.

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Acknowledgments

The authors thank Dr. Tadaaki Yamada, Shionogi & Co., Ltd., Department of Biostatistics, for technical assistance regarding statistical analysis.

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Authors and Affiliations

  1. Department of Surgery and Clinical Oncology (E2), Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita,Kinetics (D9), Osaka, 565-0871, Japan

    Hiroki Fukunaga MD, Mitsugu Sekimoto MD, PhD, Masataka Ikeda MD, PhD, Ichiro Higuchi MD, Masayoshi Yasui MD, Iwao Seshimo MD, Osamu Takayama MD, Hirofumi Yamamoto MD, PhD, Masayuki Ohue MD, PhD & Morito Monden MD, PhD

  2. Department of Nuclear Medicine and Tracer Kinetics (D9), Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Mitsuaki Tatsumi MD, PhD & Jun Hatazawa MD, PhD

  3. Department of Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Osaka, Japan

    Masakazu Ikenaga MD, PhD

  4. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto, 602-8566, Japan

    Tsunehiko Nishimura MD, PhD

Authors
  1. Hiroki Fukunaga MD
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  2. Mitsugu Sekimoto MD, PhD
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  3. Masataka Ikeda MD, PhD
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  4. Ichiro Higuchi MD
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  6. Iwao Seshimo MD
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  7. Osamu Takayama MD
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  8. Hirofumi Yamamoto MD, PhD
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  9. Masayuki Ohue MD, PhD
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  10. Mitsuaki Tatsumi MD, PhD
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  11. Jun Hatazawa MD, PhD
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  12. Masakazu Ikenaga MD, PhD
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  14. Morito Monden MD, PhD
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Corresponding author

Correspondence to Mitsugu Sekimoto MD, PhD.

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Fukunaga, H., Sekimoto, M., Ikeda, M. et al. Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer. Ann Surg Oncol 12, 561–569 (2005). https://doi.org/10.1245/ASO.2005.08.001

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  • DOI: https://doi.org/10.1245/ASO.2005.08.001

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