Abstract: Gastric cancer is one of the most common malignant tumors. Due to late diagnosis and less effective treatment in some cases, the overall survival rate is poor. In recent years, chimeric antigen receptor T cell (CAR-T cell) therapy has received considerable attention in the field of cancer treatment and has played an important role in the treatment of hematological tumors. However, the theraputic efficacy in solid tumors are affected by target specificity, the tumor microenvironment, and other factors. Various preclinical and clinical trials have demonstrated that CAR-T cell immunotherapy is a promising treatment approach for gastric cancer. It exhibits different advantages when treating other solid tumors but still faces many challenges in development. In this review, the latest research progress in CAR-T therapy in gastric cancer will be examined.