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NEUROLOGY 2006;67:2250-2252
© 2006 American Academy of Neurology
Brief Communications

CNS involvement in hereditary neuropathy with pressure palsies (HNPP)

B. Tackenberg, MD, J. C. Möller, MD, H. Rindock, S. Bien, MD, N. Sommer, MD, W. H. Oertel, MD, F. Rosenow, MD, K. Schepelmann, MD, H. M. Hamer, MD and O. Bandmann, MD, PhD

From the Department of Neurology (B.T., J.C.M., H.R., N.S., W.H.O., F.R., K.S., H.M.H.) and Department of Neuroradiology (S.B.), Philipps-University, Marburg, Germany; and the Academic Neurology Unit, Division of Genomic Medicine, Sheffield, UK (O.B.).

Address correspondence and reprint requests to Dr. Oliver Bandmann, Academic Neurology Unit, Division of Genomic Medicine, E Floor Medical School, Beech Hill Road, UK-Sheffield S10 2RX, United Kingdom; e-mail: O.Bandmann{at}sheffield.ac.uk

We assessed seven patients with hereditary neuropathy with liability to pressure palsies (HNPP) with 16 electrophysiological tests and cranial MRI for CNS abnormalities. Mean latencies differed between patients with HNPP and controls for the blink reflex, the jaw-opening reflex, and acoustic evoked potentials. MRI abnormalities were observed in four patients. Our study suggests subclinical but functionally relevant CNS myelin damage in HNPP.

Supported by Förderverein Neurologie zur Forschung und Ausbildung e. V. (FN), D-35033 Marburg, Germany.

Disclosure: The authors report no conflicts of interest

Received March 28, 2006. Accepted in final form August 31, 2006.




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Y. Iwasaki, H. Iguchi, K. Ikeda, and O. Kano
CNS INVOLVEMENT IN HEREDITARY NEUROPATHY WITH PRESSURE PALSIES (HNPP)
Neurology, June 5, 2007; 68(23): 2046 - 2046.
[Full Text] [PDF]

Correspondence:

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CNS involvement in hereditary neuropathy with pressure palsies (HNPP)
Yasuo Iwasaki, et al.
Neurology Online, 12 Mar 2007 [Full text]

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